Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases
نویسندگان
چکیده
منابع مشابه
Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases
BACKGROUND New tools are required to improve tuberculosis (TB) diagnosis and treatment, including enhanced ability to compare new treatment strategies. The ELISPOT assay uses Mycobacterium tuberculosis-specific antigens to produce a precise quantitative readout of the immune response to pathogen. We hypothesized that TB patients in The Gambia would have reduced ELISPOT counts after successful t...
متن کاملIncidence of Tuberculosis and the Predictive Value of ELISPOT and Mantoux Tests in Gambian Case Contacts
BACKGROUND Studies of Tuberculosis (TB) case contacts are increasingly being utilised for understanding the relationship between M. tuberculosis and the human host and for assessing new interventions and diagnostic tests. We aimed to identify the incidence rate of new TB cases among TB contacts and to relate this to their initial Mantoux and ELISPOT test results. METHODS AND FINDINGS After in...
متن کاملCan ELISpot replace the tuberculin skin test for latent tuberculosis?
BACKGROUND Screening and treatment of latent tuberculosis infection (LTBI) prior to anti-tumour necrosis factor alpha (anti-TNF-alpha) therapy has been shown to decrease the incidence of active tuberculosis (TB) by more than 80%, and is recommended by the British Thoracic Society. In the absence of a gold standard test for LTBI, conventional screening currently involves taking a clinical histor...
متن کاملReversion and conversion of Mycobacterium tuberculosis IFN-γ ELISpot results during anti-tuberculous treatment in HIV-infected children
BACKGROUND Recent interest has focused on the potential use of serial interferon gamma (IFN-gamma) release assay (IGRA) measurements to assess the response to anti-tuberculous (TB) treatment. The kinetics of IFN-gamma responses to Mycobacterium tuberculosis (MTB) antigens in HIV-infected children during treatment have not however been previously investigated. METHODS IFN-gamma responses to th...
متن کاملLongitudinal Assessment of an ELISPOT Test for Mycobacterium tuberculosis Infection
BACKGROUND Very little longitudinal information is available regarding the performance of T cell-based tests for Mycobacterium tuberculosis infection. To address this deficiency, we conducted a longitudinal assessment of the enzyme-linked immunosorbent spot test (ELISPOT) test in comparison to the standard tuberculin skin test (TST). METHODS AND FINDINGS In tuberculosis (TB) contacts we repea...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2006
ISSN: 1471-2334
DOI: 10.1186/1471-2334-6-66